- May 11, 2019
It'll be interesting to see comment about this. Received wisdom has been that gastric acidity during the SN ingestion process is undesirable.The paper which appear in the answer above (https://www.ncbi.nlm.nih.gov/pubmed/27802417) has an interesting phrase in it:
"We conclude that the acute blood pressure-lowering effect of nitrite requires an acidic gastric environment. "
It appears that maybe specifically the blood pressure-lowering effect of SN are stronger on an acidic stomach. And it's not that PPIs specifically attack that, but antacids in general.
At least, that was my understanding.
Anyway, does the hypotension thing really matter in the SN process ? The killing mechanism prevents the blood from transporting and releasing oxygen to the various organs of the body, including, crucially, the brain, and the increased heart rate plus hypotension (low BP) are really irrelevant to the oxygen exchange deficit.
Just a thought.